{"id":84,"date":"2017-09-15T14:46:23","date_gmt":"2017-09-15T14:46:23","guid":{"rendered":"http:\/\/www.doarj.org\/ijmhfs\/?p=84"},"modified":"2017-10-09T14:13:16","modified_gmt":"2017-10-09T14:13:16","slug":"the-relationship-between-levels-of-cysteine-and-activation-of-p65p50-subunits-of-nf-b-in-children-with-marasmus-type-malnutrition","status":"publish","type":"post","link":"https:\/\/www.tdoarj.org\/ijmhfs\/the-relationship-between-levels-of-cysteine-and-activation-of-p65p50-subunits-of-nf-b-in-children-with-marasmus-type-malnutrition\/","title":{"rendered":"THE RELATIONSHIP BETWEEN LEVELS OF CYSTEINE AND ACTIVATION OF P65,P50 SUBUNITS OF NF-B IN CHILDREN WITH MARASMUS TYPE MALNUTRITION"},"content":{"rendered":"<p><strong>Budy Krestanto, Dian Handayani, Anik Puryatni<\/strong><\/p>\n<p><strong>Abstract<\/strong><em><br \/>\n<strong>Background<\/strong>: <\/em>Decreasing levels of cysteine \u200b\u200bare known to cause changes in the redox environment. GSH proved antioxidants can lower the reduction potential of GSSG\/2GSH and activation of NF-kB. Many studies have proven the benefits of cysteine \u200b\u200bin patients with protein malnutrition, but there is no research to prove the role of cysteine \u200b\u200bin patients with marasmus type malnutrition. <strong><em>Aims<\/em><\/strong><em>:<\/em> To determine the relationship between levels of cysteine \u200b\u200band activation of NF-kB in children with marasmus type malnutrition.<em> <strong>Methods<\/strong>:<\/em> This study was an observational analytic study using cross-sectional design. The cysteine \u200b\u200band activation of p65,p50 subunits of NF-kB measured in two groups as marasmus type malnutrition and controls of well-nourished children. Marasmus type malnutrition consisting of 18 children and controls consisting of 18 well-nourished children. The levels of cysteine was measured using ELISA<em>, <\/em>while activation of p65,p50 subunits of NF-kB examined using flowcytometry method. <strong><em>Results<\/em><\/strong><em>: <\/em>The results of this study showed that an average of cysteine level ranking of marasmus type malnutrition group was lower compared to well-nourished group (11.33 vs 25.67 pg\/mL; p&lt;0.005). The activation of p65 subunits of NF-kB average in the group of marasmus type malnutrition was lower than control (61.65\u00b15.00 vs 65.28\u00b13.29; p&lt;0.005), while activation of p50 subunits of NF-kB was not significantly different between marasmus type malnutrition group and control (15.47 vs 21.53; p=0.085). The Spearman correlation between levels of cysteine \u200b\u200band activation of p65 subunits of NF-kB in children with marasmus type malnutrition showed no significant correlation (r=-0.012; p=0.961), likewise between cysteine and activation of p50 subunits of NF-kB also indicated no significant correlation (r=-0.428; p=0.076).<strong> <em>Conclusion<\/em><\/strong><em>: <\/em>Cysteine \u200b\u200blevels and activation of p65,p50 subunits of NF-kB in children with marasmus type malnutrition were significantly lower compared with well-nourished children. There was no significant correlation between the levels of cysteine \u200b\u200bwith the activation of p65,p50 subunits of NF-kB in patients with marasmus type malnutrition.<\/p>\n<p><strong><em>Keywords<\/em><\/strong><em>: cysteine levels, activation of p65,p50 subunits of NF-kB, children, marasmus type malnutrition<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>Full Text: <a class=\"file\" href=\"https:\/\/www.tdoarj.org\/ijmhfs\/wp-content\/uploads\/2017\/IJMHFS\/9-2017\/2%20Doarj%20-%20The%20Relationship%20Between%20Levels%20Of%20Cysteine%20And%20Activation%20Of%20P65,P50%20Subunits%20Of%20Nf-B%20In%20Children%20With%20Marasmus%20Type%20Malnutrition.pdf\">PDF<\/a><\/p>\n\n<div class=\"gde-error\">GDE Error: Requested URL is invalid<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Budy Krestanto, Dian Handayani, Anik Puryatni Abstract Background: Decreasing levels of cysteine \u200b\u200bare known to cause changes in the redox environment. GSH proved antioxidants can lower the reduction potential of GSSG\/2GSH and activation of NF-kB. Many studies have proven the benefits of cysteine \u200b\u200bin patients with protein malnutrition, but there is no research to prove [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/posts\/84"}],"collection":[{"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/comments?post=84"}],"version-history":[{"count":1,"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/posts\/84\/revisions"}],"predecessor-version":[{"id":85,"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/posts\/84\/revisions\/85"}],"wp:attachment":[{"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/media?parent=84"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/categories?post=84"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tdoarj.org\/ijmhfs\/wp-json\/wp\/v2\/tags?post=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}