Maria Agnes Etty Dedy, Pius Weraman, Hari Rarindo, and Rafael Paun

ABSTRACT

Children under five with malnutrition likely to be more susceptible to TB because of damage to the cells of Cell Mediated Immunity (CMI) as a result of malnutrition itself. The success of treatment against TB is one among other indicators to control morbidity and mortality rates due to TB incidence on children under five. From the pharmacokinetics aspect, the protein plasma binding determines amount of drug that can reach out the receptor. On the children under five with malnutrition who suffer from TB, the amount of protein is less; therefore, it will be only slightly active drug substance which can bind to proteins of blood plasma. The kind of research used was observational analytic with case-control design. The research was conducted in the Timor Tengah Selatan (TTS) District with total samples were 72 respondents. The determinant for the success of treatment was the children under five suffering from TB without malnutrition complication risk were likely to succeed in treatment at 14,154 times greater, compared to the children under five with malnutrition complications. It is recommended that the TTS District government needs to enforce a regulation which aims to raise awareness and foster a sense of all parties towards the high incidence of malnutrition over the district area, given that is is an indirect cause which will trigger the emergence of other diseases, as well as minimize the chances for success of a treatment. This study is expected to be as a basis for dose adjustment in order to increase the chances of the success of TB treatment on children under five.

Key Words: Children under five TB, success treatment, malnutrition, TTS District

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